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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Thyroxine 5-deiodinase ： ウィキペディア英語版 Thyroxine 5-deiodinase Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.97.1.1) is an enzyme that in humans is encoded by the ''DIO3'' gene. This enzyme catalyses the following chemical reaction : 3,3',5'-triiodo-L-thyronine + iodide + A + H+ $\backslash rightleftharpoons$ L-thyroxine + AH2 The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development.〔 == Discovery == The gene was mapped to chromosome 14q32 using fluorescence in situ hybridization (FISH) in 1998.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Thyroxine 5-deiodinase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.